The Alexandrian Remix is an awesome take on Waterdeep: Dragon Heist. While the original requires you to choose a single antagonist, the remix throws all four at you. Your party will be contending with the Cassalanters, Manshoon, Jarlaxle, and Xanathar at the same time. In my campaign, I even added the Open Lord as a fifth faction.
In my opinion, opening up the list of bad guys gives you, the DM, a real opportunity to make the world come alive for your players. However, it can get really complicated really fast.
To help navigate all of the interactions, I modified the original node map to add the Open Lord and make it a little more usable. You can find a high-res copy of the file on Patreon.